2015 August 31 Plant Signaling and Behavior 10(8):
Receptor for Activated C Kinase 1 (RACK1) is a versatile scaffold
protein that interacts with a large, diverse group of proteins to
regulate various signaling cascades. RACK1 has been shown to regulate
hormonal signaling, stress responses and multiple processes of growth
and development in plants. However, little is known about the molecular
mechanism underlying these regulations. Recently, it has been
demonstrated that Arabidopsis RACK1 is phosphorylated by an atypical
serine/threonine protein kinase, WITH NO LYSINE 8 (WNK8). Furthermore,
RACK1 phosphorylation by WNK8 negatively regulates RACK1 function by
influencing its protein stability. These findings promote a new
regulatory system in which the action of RACK1 is controlled by
phosphorylation and subsequent protein degradation.
Jin-Gui Chen. Phosphorylation of RACK1 in plants. Plant Signaling & Behavior, Vol. 10, Issue 8, 2015.